The average bus between Pisa Centrale and Rome Termini takes 5h 31m and the fastest bus takes 4h 55m. The bus service runs several times per day from Pisa Centrale to Rome Termini. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Pisa Centrale and Rome Termini. The earliest departure is at 12:25 AM at night, and the last departure from Pisa Centrale is at 10:00 PM which arrives into Rome Termini at 2:55 AM. All services require a transfer at Pisa and take an average of 5h 31m. The schedules shown below are for the next available departures.

5h 53m • 1 change

5h 17m • 1 change

5h 38m • 1 change
Arrives next day

4h 55m • 1 change

5h 53m • 1 change

5h 17m • 1 change

5h 38m • 1 change

5h 38m • 1 change

6h 6m • 1 change

5h 14m • 1 change

5h 34m • 1 change

5h 29m • 1 change

6h 6m • 1 change

5h 14m • 1 change

5h 34m • 1 change

5h 29m • 1 change
Want to know about travelling from Pisa Centrale to Rome Termini? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pisa Centrale to Rome Termini. However, there are services departing from Pisa Centrale station and arriving at Rome Termini station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 5h 31m.
Pisa Centrale to Rome Termini bus services, operated by FlixBus, depart from Pisa station.
Pisa Centrale to Rome Termini bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
The distance between Pisa Centrale and Rome Termini is 264.1 km. The road distance is 362 km.
FlixBus operates a bus from Pisa to Roma, Autostazione Tiburtina 3 times a day. Tickets cost €30–50 and the journey takes 5h 30m.