The average bus between Pisa Centrale and Sicily takes 23h 34m and the fastest bus takes 22h 32m. The bus service runs several times per day from Pisa Centrale to Sicily. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Pisa Centrale and Sicily. The earliest departure is at 4:45 AM at night, and the last departure from Pisa Centrale is at 5:10 PM which arrives into Sicily at 3:43 PM. All services require a transfer at Pisa and take an average of 23h 34m. The schedules shown below are for the next available departures.
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23h 23m • 2 changesArrives next day


22h 33m • 2 changesArrives next day


23h 27m • 2 changesArrives next day


22h 32m • 2 changesArrives next day


23h 23m • 2 changesArrives next day


22h 33m • 2 changesWant to know about travelling from Pisa Centrale to Sicily? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pisa Centrale to Sicily. However, there are services departing from Pisa Centrale station and arriving at Sicily station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 23h 34m.
Pisa Centrale to Sicily bus services, operated by FlixBus, depart from Pisa station.
Pisa Centrale to Sicily bus services, operated by FlixBus, arrive at Palermo station.
The distance between Pisa Centrale and Sicily is 750.5 km. The road distance is 1,376 km.
You can take a vehicle from Pisa Centrale to Piazza Boiardo via Pisa, Florence Villa Constanza Bus Station, Palermo, and Stazione Centrale Pensilina Esterna in around 20h 25m.