The average bus between Pisa and Roma Ostiense takes 6h 36m and the fastest bus takes 5h 10m. There is at least one bus per day from Pisa to Roma Ostiense. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Pisa and Roma Ostiense. The earliest departure is at 5:25 PM in the evening, and the last departure from Pisa is at 10:00 PM which arrives into Roma Ostiense at 3:10 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 6h 36m. The schedules shown below are for the next available departures.
Arrives next day

6h 59m • 1 change
Arrives next day

5h 10m • 1 change
Arrives next day

8h 54m • 1 change
Arrives next day

5h 23m • 1 change
Want to know about travelling from Pisa to Roma Ostiense? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pisa to Roma Ostiense. However, there are services departing from Pisa station and arriving at Roma Ostiense station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 6h 36m.
Pisa to Roma Ostiense bus services, operated by FlixBus, depart from Pisa station.
Pisa to Roma Ostiense bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
The distance between Pisa and Roma Ostiense is 265.5 km. The road distance is 366 km.
FlixBus operates a bus from Pisa to Roma, Autostazione Tiburtina 3 times a day. Tickets cost €30–55 and the journey takes 5h 30m.