The average bus between Pittsburgh and Mechanicsburg takes 6h 23m and the fastest bus takes 4h 46m. The bus service runs several times per day from Pittsburgh to Mechanicsburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Pittsburgh and Mechanicsburg. The earliest departure is at 1:40 AM at night, and the last departure from Pittsburgh is at 9:45 PM which arrives into Mechanicsburg at 5:58 AM. All services require a transfer at Harrisburg Bus Station and take an average of 6h 23m. The schedules shown below are for the next available departures.

5h 43m • 1 change

5h 58m • 1 change

7h 45m • 1 change

6h 3m • 1 change

4h 46m • 1 change

5h 43m • 1 change

5h 58m • 1 change

7h 40m • 1 change

4h 46m • 1 change

5h 43m • 1 change

5h 58m • 1 change

7h 40m • 1 change

6h 1m • 1 change

5h 11m • 1 change

6h 41m • 1 change

7h 26m • 1 change

4h 46m • 1 change

5h 43m • 1 change

5h 58m • 1 change

7h 40m • 1 change

4h 46m • 1 change

5h 43m • 1 change

5h 58m • 1 change

7h 45m • 1 change
Want to know about travelling from Pittsburgh to Mechanicsburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pittsburgh to Mechanicsburg. However, there are services departing from Pittsburgh station and arriving at Mechanicsburg station via Harrisburg Bus Station station. The journey, including transfers, takes approximately 6h 23m.
Pittsburgh to Mechanicsburg bus services, operated by Greyhound USA, depart from Pittsburgh Intermodal Station.
Pittsburgh to Mechanicsburg bus services, operated by Greyhound USA, arrive at Harrisburg Bus Station.
The distance between Pittsburgh and Mechanicsburg is 254.8 km. The road distance is 334 km.
Greyhound USA operates a bus from Pittsburgh Intermodal Station to Harrisburg Bus Station every 4 hours. Tickets cost $30–65 and the journey takes 4h 10m. Flixbus USA also services this route twice daily.