Pittsburgh to Mechanicsburg Buses

Pittsburgh to Mechanicsburg buses

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Trip Overview

The average bus between Pittsburgh and Mechanicsburg takes 6h 20m and the fastest bus takes 4h 46m. The bus service runs several times per day from Pittsburgh to Mechanicsburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 20m
Duration: 207 mi
Distance: $43
Average price: 4 times a day
Frequency

Bus

best

Take the bus from Pittsburgh Intermodal Station to Harrisburg Bus Stationbus Greyhound US0421 / ...

4h 59m

$32–54

Pittsburgh to Mechanicsburg bus times

Buses run 4 times a day between Pittsburgh and Mechanicsburg. The earliest departure is at 1:40 AM at night, and the last departure from Pittsburgh is at 9:45 PM which arrives into Mechanicsburg at 5:58 AM. All services require a transfer at Harrisburg Bus Station and take an average of 6h 20m. The schedules shown below are for the next available departures.

Departing Thursday, October 22, 2026

1:40 AM → 6:26 AM
4h 46m • 1 change
6:15 AM → 11:07 AM
4h 52m • 1 change
8:30 AM → 1:58 PM
5h 28m • 1 change
9:35 AM → 4:55 PM
7h 20m • 1 change
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Departing Friday, October 23, 2026

1:40 AM → 6:26 AM
4h 46m • 1 change
6:15 AM → 11:07 AM
4h 52m • 1 change
8:30 AM → 1:58 PM
5h 28m • 1 change
9:35 AM → 4:55 PM
7h 20m • 1 change
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Departing Saturday, October 24, 2026

1:40 AM → 7:41 AM
6h 1m • 1 change
7:30 AM → 12:41 PM
5h 11m • 1 change
8:30 AM → 2:41 PM
6h 11m • 1 change
9:35 AM → 4:41 PM
7h 6m • 1 change

Departing Sunday, October 25, 2026

9:45 PM → 5:58 AM
Arrives next day
8h 13m • 1 change

Departing Monday, October 26, 2026

1:40 AM → 6:26 AM
4h 46m • 1 change
6:15 AM → 11:07 AM
4h 52m • 1 change
7:30 AM → 1:58 PM
6h 28m • 1 change
9:35 AM → 4:55 PM
7h 20m • 1 change
Show more

Departing Tuesday, October 27, 2026

1:40 AM → 6:26 AM
4h 46m • 1 change
6:15 AM → 11:07 AM
4h 52m • 1 change
7:30 AM → 1:58 PM
6h 28m • 1 change
9:10 AM → 4:55 PM
7h 45m • 1 change
Show more

Departing Wednesday, October 28, 2026

1:40 AM → 6:26 AM
4h 46m • 1 change
6:15 AM → 11:07 AM
4h 52m • 1 change
9:10 AM → 4:55 PM
7h 45m • 1 change

Frequently asked questions

Want to know about travelling from Pittsburgh to Mechanicsburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Pittsburgh to Mechanicsburg buses

Trip Overview

Bus