The average bus between Pittsburgh and Middletown takes 6h 36m and the fastest bus takes 5h 2m. The bus service runs several times per day from Pittsburgh to Middletown. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Pittsburgh and Middletown. The earliest departure is at 1:40 AM at night, and the last departure from Pittsburgh is at 9:45 PM which arrives into Middletown at 5:57 AM. All services require a transfer at Harrisburg Bus Station and take an average of 6h 36m. The schedules shown below are for the next available departures.

5h 2m • 1 change

5h 49m • 1 change

5h 34m • 1 change

8h 4m • 1 change

5h 2m • 1 change

5h 49m • 1 change

5h 34m • 1 change

8h 9m • 1 change

5h 2m • 1 change

5h 49m • 1 change

5h 34m • 1 change

8h 9m • 1 change

5h 2m • 1 change

5h 49m • 1 change

5h 34m • 1 change

8h 4m • 1 change

5h 2m • 1 change

5h 49m • 1 change

5h 34m • 1 change

8h 4m • 1 change
Want to know about travelling from Pittsburgh to Middletown? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pittsburgh to Middletown. However, there are services departing from Pittsburgh station and arriving at Middletown station via Harrisburg Bus Station station. The journey, including transfers, takes approximately 6h 36m.
Pittsburgh to Middletown bus services, operated by Flixbus USA, depart from Pittsburgh Intermodal Station.
Pittsburgh to Middletown bus services, operated by Flixbus USA, arrive at Harrisburg Bus Station.
Book your Pittsburgh to Middletown bus tickets online with Flixbus USA, Rabbit Transit and Greyhound USA.
The distance between Pittsburgh and Middletown is 278.1 km. The road distance is 344 km.
Greyhound USA operates a bus from Pittsburgh Intermodal Station to Harrisburg Bus Station hourly. Tickets cost $30–60 and the journey takes 4h 10m. Flixbus USA also services this route 4 times a day.