Pittsburgh to Middletown (Station) Buses

Pittsburgh to Middletown (Station) buses

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Trip Overview

The average bus between Pittsburgh and Middletown (Station) takes 6h 11m and the fastest bus takes 4h 49m. The bus service runs several times per day from Pittsburgh to Middletown (Station). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 11m
Duration: 210 mi
Distance: $43
Average price: 5 times a day
Frequency

Bus

best

Take the bus from Pittsburgh Intermodal Station to Harrisburg Bus Stationbus Greyhound US0421 / ...

5h 1m

$32–54

Pittsburgh to Middletown (Station) bus times

Buses run 5 times a day between Pittsburgh and Middletown (Station). The earliest departure is at 1:40 AM at night, and the last departure from Pittsburgh is at 9:45 PM which arrives into Middletown (Station) at 5:44 AM. All services require a transfer at Harrisburg Bus Station and take an average of 6h 11m. The schedules shown below are for the next available departures.

Departing Saturday, October 24, 2026

9:35 AM → 5:28 PM
7h 53m • 1 change
1:00 PM → 7:28 PM
6h 28m • 1 change

Departing Sunday, October 25, 2026

9:45 PM → 5:44 AM
Arrives next day
7h 59m • 1 change

Departing Monday, October 26, 2026

1:40 AM → 6:29 AM
4h 49m • 1 change
6:15 AM → 11:05 AM
4h 50m • 1 change
7:30 AM → 1:20 PM
5h 50m • 1 change
9:35 AM → 4:14 PM
6h 39m • 1 change
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Departing Tuesday, October 27, 2026

1:40 AM → 6:29 AM
4h 49m • 1 change
6:15 AM → 11:05 AM
4h 50m • 1 change
7:30 AM → 1:20 PM
5h 50m • 1 change
9:10 AM → 4:14 PM
7h 4m • 1 change
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Departing Wednesday, October 28, 2026

1:40 AM → 6:29 AM
4h 49m • 1 change
6:15 AM → 11:05 AM
4h 50m • 1 change
9:10 AM → 4:14 PM
7h 4m • 1 change
8:00 PM → 5:44 AM
Arrives next day
9h 44m • 1 change

Departing Thursday, October 29, 2026

1:40 AM → 6:29 AM
4h 49m • 1 change
6:15 AM → 11:05 AM
4h 50m • 1 change
8:30 AM → 1:20 PM
4h 50m • 1 change
9:35 AM → 4:14 PM
6h 39m • 1 change
Show more

Departing Friday, October 30, 2026

1:40 AM → 6:29 AM
4h 49m • 1 change
6:15 AM → 11:05 AM
4h 50m • 1 change
8:30 AM → 1:20 PM
4h 50m • 1 change
9:35 AM → 4:14 PM
6h 39m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Pittsburgh to Middletown (Station)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Pittsburgh to Middletown (Station) buses

Trip Overview

Bus