The average bus between Plymouth and Slough takes 5h 59m and the fastest bus takes 5h 12m. The bus service runs several times per day from Plymouth to Slough. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Plymouth and Slough. The earliest departure is at 12:30 AM at night, and the last departure from Plymouth is at 3:45 PM which arrives into Slough at 8:57 PM. All services require a transfer, and take on average 5h 59m. The schedules shown below are for the next available departures.

5h 58m • 1 change

5h 48m • 1 change

5h 29m • 1 change

6h 44m • 1 change

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5h 56m • 1 change

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5h 15m • 1 change

6h 38m • 1 change

5h 55m • 1 change

5h 43m • 1 change

5h 14m • 1 change

6h 35m • 1 change

5h 58m • 1 change

5h 48m • 1 change

5h 29m • 1 change

6h 44m • 1 change

5h 58m • 1 change

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5h 29m • 1 change

6h 44m • 1 change
Want to know about travelling from Plymouth to Slough? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Plymouth to Slough. However, there are services departing from Plymouth station and arriving at Slough station via Heathrow Central Bus Station station. The journey, including transfers, takes approximately 5h 59m.
Plymouth to Slough bus services, operated by National Express, depart from Plymouth Coach Station.
Plymouth to Slough bus services, operated by National Express, arrive at Heathrow Central Bus Station.
Book your Plymouth to Slough bus tickets online with National Express and First Berkshire & The Thames Valley.
The distance between Plymouth and Slough is 278.9 km. The road distance is 339 km.
National Express operates a bus from Plymouth Coach Station to Heathrow Central Bus Station every 2 hours. Tickets cost £35–95 and the journey takes 4h 55m.