Point Loma to Irvine Buses

Trip Overview

The average bus between Point Loma and Irvine takes 3h 51m and the fastest bus takes 3h 11m. The bus service runs several times per day from Point Loma to Irvine. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 51m
Duration: 107 mi
Distance: $24
Average price: 4 times a day
Frequency

Bus, line 53 bus

best

Take the bus from San Diego to Anaheim Regional Transportation Intermodal Centerbus FlixBus N2003 / ...
Take the bus from Artic - Dock 4 to Main-Harvardbus 53

4h 3m

$18–30

Point Loma to Irvine bus times

Buses run 4 times a day between Point Loma and Irvine. The earliest departure is at 7:47 AM in the morning, and the last departure from Point Loma is at 9:49 PM which arrives into Irvine at 1:00 AM. All services require a transfer at Old Town Transit Center and take an average of 3h 51m. The schedules shown below are for the next available departures.

Departing Friday, October 9, 2026

7:18 PM → 10:32 PM
3h 14m • 2 changes
9:49 PM → 1:00 AM
Arrives next day
3h 11m • 2 changes

Departing Saturday, October 10, 2026

7:49 AM → 11:39 AM
3h 50m • 2 changes
11:15 AM → 2:39 PM
3h 24m • 2 changes
11:45 AM → 4:09 PM
4h 24m • 2 changes
7:18 PM → 10:50 PM
3h 32m • 2 changes

Departing Sunday, October 11, 2026

7:48 PM → 4:46 AM
Arrives next day
8h 58m • 2 changes

Departing Monday, October 12, 2026

7:47 AM → 11:44 AM
3h 57m • 2 changes
11:15 AM → 2:41 PM
3h 26m • 2 changes
11:45 AM → 4:11 PM
4h 26m • 2 changes
7:18 PM → 10:32 PM
3h 14m • 2 changes
Show more

Departing Tuesday, October 13, 2026

11:15 AM → 2:41 PM
3h 26m • 2 changes
11:45 AM → 4:11 PM
4h 26m • 2 changes
7:18 PM → 10:32 PM
3h 14m • 2 changes
9:49 PM → 1:00 AM
Arrives next day
3h 11m • 2 changes

Departing Wednesday, October 14, 2026

7:47 AM → 11:44 AM
3h 57m • 2 changes
11:15 AM → 2:41 PM
3h 26m • 2 changes
7:18 PM → 10:32 PM
3h 14m • 2 changes
9:49 PM → 1:00 AM
Arrives next day
3h 11m • 2 changes

Departing Thursday, October 15, 2026

7:47 AM → 11:44 AM
3h 57m • 2 changes
11:15 AM → 2:41 PM
3h 26m • 2 changes
11:45 AM → 4:11 PM
4h 26m • 2 changes

Frequently asked questions

Want to know about travelling from Point Loma to Irvine? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

What companies run services between Point Loma, CA, USA and Irvine, CA, USA?

You can take a bus from Rosecrans St & Canon St to Main-Harvard via Old Town Transit Center, San Diego, Anaheim Regional Transportation Intermodal Center, and Artic - Dock 4 in around 4h 3m.

Operators

Trip Overview

Bus, line 53 bus

Point Loma to Irvine bus times

Departing Friday, October 9, 2026

7:18 PM → 10:32 PM

9:49 PM → 1:00 AM
Arrives next day

Departing Saturday, October 10, 2026

7:49 AM → 11:39 AM

11:15 AM → 2:39 PM

11:45 AM → 4:09 PM

7:18 PM → 10:50 PM

Departing Sunday, October 11, 2026

7:48 PM → 4:46 AM
Arrives next day

Departing Monday, October 12, 2026

7:47 AM → 11:44 AM

11:15 AM → 2:41 PM

11:45 AM → 4:11 PM

7:18 PM → 10:32 PM

Departing Tuesday, October 13, 2026

11:15 AM → 2:41 PM

11:45 AM → 4:11 PM

7:18 PM → 10:32 PM

9:49 PM → 1:00 AM
Arrives next day

Departing Wednesday, October 14, 2026

7:47 AM → 11:44 AM

11:15 AM → 2:41 PM

7:18 PM → 10:32 PM

9:49 PM → 1:00 AM
Arrives next day

Departing Thursday, October 15, 2026

7:47 AM → 11:44 AM

11:15 AM → 2:41 PM

11:45 AM → 4:11 PM

Frequently asked questions

What companies run services between Point Loma, CA, USA and Irvine, CA, USA?

Bus from San Diego to Anaheim Regional Transportation Intermodal Center

Point Loma to Irvine buses

Find Transport to Irvine

Trip Overview

Bus, line 53 bus

Point Loma to Irvine bus times

Departing Friday, October 9, 2026

7:18 PM → 10:32 PM

9:49 PM → 1:00 AMArrives next day

Departing Saturday, October 10, 2026

7:49 AM → 11:39 AM

11:15 AM → 2:39 PM

11:45 AM → 4:09 PM

7:18 PM → 10:50 PM

Departing Sunday, October 11, 2026

7:48 PM → 4:46 AMArrives next day

Departing Monday, October 12, 2026

7:47 AM → 11:44 AM

11:15 AM → 2:41 PM

11:45 AM → 4:11 PM

7:18 PM → 10:32 PM

Departing Tuesday, October 13, 2026

11:15 AM → 2:41 PM

11:45 AM → 4:11 PM

7:18 PM → 10:32 PM

9:49 PM → 1:00 AMArrives next day

Departing Wednesday, October 14, 2026

7:47 AM → 11:44 AM

11:15 AM → 2:41 PM

7:18 PM → 10:32 PM

9:49 PM → 1:00 AMArrives next day

Departing Thursday, October 15, 2026

7:47 AM → 11:44 AM

11:15 AM → 2:41 PM

11:45 AM → 4:11 PM

Frequently asked questions

What companies run services between Point Loma, CA, USA and Irvine, CA, USA?

Bus from San Diego to Anaheim Regional Transportation Intermodal Center

Bus trips from Point Loma

Bus trips to Irvine

Alternative transport options

9:49 PM → 1:00 AM
Arrives next day

7:48 PM → 4:46 AM
Arrives next day

9:49 PM → 1:00 AM
Arrives next day

9:49 PM → 1:00 AM
Arrives next day