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Port Saint Lucie to Durham buses

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Trip Overview

The bus between Port Saint Lucie and Durham takes 44h 5m. The bus runs, on average, 3 times per week from Port Saint Lucie to Durham. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

44h 5m
Duration
927 mi
Distance
$193
Average price
3 times a week
Frequency

Port Saint Lucie to Durham bus times

Buses run 3 times a week between Port Saint Lucie and Durham. The service departs Port Saint Lucie at 8:45 AM in the morning, which arrives into Durham at 04:50:00. All services require a transfer at Fort Lauderdale - Broward Blvd Park and Ride and take an average of 44h 5m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Jet Set ExpressFlixbus USAFlixbus USAGreyhound USA44h 5m • 3 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives +2 days

    Jet Set ExpressFlixbus USAFlixbus USAGreyhound USA44h 5m • 3 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Jet Set ExpressFlixbus USAFlixbus USAGreyhound USA44h 5m • 3 changes

Frequently asked questions

Want to know about travelling from Port Saint Lucie to Durham? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Port Saint Lucie to Durham.ExpandLaunch map view
  • Distance: 927.3 mi
  • Duration: 44h 5m

What companies run services between Port Saint Lucie, FL, USA and Durham, NC, USA?

You can take a bus from Fort Pierce to Durham via Fort Lauderdale - Broward Blvd Park and Ride, Ft Lauderdale Broward Park & Ride, Fayetteville Bus Station, and Raleigh Bus Station in around 21h.

Operators