The average bus between Port Saint Lucie and Durham takes 19h 57m and the fastest bus takes 18h 5m. The bus service runs several times per day from Port Saint Lucie to Durham. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Port Saint Lucie and Durham. The earliest departure is at 9:45 AM in the morning, and the last departure from Port Saint Lucie is at 7:10 PM which arrives into Durham at 4:50 AM. All services require a transfer at Orlando RedCoach Station and take an average of 19h 57m. The schedules shown below are for the next available departures.
Arrives next day




19h 5m • 4 changes
Arrives next day




18h 5m • 4 changes
Arrives next day




19h 5m • 4 changes
Arrives next day




18h 5m • 4 changes
Arrives +2 days




33h 40m • 4 changes
Want to know about travelling from Port Saint Lucie to Durham? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Port Saint Lucie to Durham. However, there are services departing from Port Saint Lucie station and arriving at Durham station via Orlando RedCoach Station station. The journey, including transfers, takes approximately 19h 57m.
Port Saint Lucie to Durham bus services, operated by RedCoach, depart from Fort Pierce station.
Port Saint Lucie to Durham bus services, operated by RedCoach, arrive at Raleigh Bus Station.
The distance between Port Saint Lucie and Durham is 977.1 km. The road distance is 1,213 km.
You can take a bus from Fort Pierce to Durham via Orlando RedCoach Station, Mccoy Rd & Gondola Dr, N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, and Raleigh Bus Station in around 16h 49m.