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Port Saint Lucie to Indianapolis buses

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Trip Overview

The bus between Port Saint Lucie and Indianapolis takes 31h 55m. The bus runs, on average, 4 times per week from Port Saint Lucie to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

31h 55m
Duration
1,131 mi
Distance
$256
Average price
4 times a week
Frequency

Port Saint Lucie to Indianapolis bus times

Buses run 4 times a week between Port Saint Lucie and Indianapolis. The service departs Port Saint Lucie at 9:00 PM at night, which arrives into Indianapolis at 04:55:00. All services require a transfer at Port St Lucie and take an average of 31h 55m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Jet Set ExpressGreyhound USAGreyhound USA31h 55m • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Jet Set ExpressGreyhound USAGreyhound USA31h 55m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    Jet Set ExpressGreyhound USAGreyhound USA31h 55m • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +2 days

    Jet Set ExpressGreyhound USAGreyhound USA31h 55m • 2 changes

Frequently asked questions

Want to know about travelling from Port Saint Lucie to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Port Saint Lucie to Indianapolis.ExpandLaunch map view
  • Distance: 1,130.6 mi
  • Duration: 31h 55m

What companies run services between Port Saint Lucie, FL, USA and Indianapolis, IN, USA?

You can take a vehicle from Port Saint Lucie to Indianapolis via Port St Lucie and Atlanta Bus Station in around 23h.

Operators