Rome2Rio

Port Saint Lucie to Key Largo buses

Find Transport to Key Largo

View schedule
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

Trip Overview

The bus between Port Saint Lucie and Key Largo takes 9h 25m. There is at least one bus per day from Port Saint Lucie to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

9h 25m
Duration
175 mi
Distance
$51
Average price
Once daily
Frequency

Port Saint Lucie to Key Largo bus times

Buses run once daily between Port Saint Lucie and Key Largo. The service departs Port Saint Lucie at 9:00 PM at night, which arrives into Key Largo at 06:25:00. All services require a transfer at Sheridan Tri-Rail Station and take an average of 9h 25m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USA9h 25m • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USA9h 25m • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USA9h 25m • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Jet Set ExpressGreyhound USAGreyhound USA9h 25m • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USA9h 25m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USA9h 25m • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USA9h 25m • 2 changes

Frequently asked questions

Want to know about travelling from Port Saint Lucie to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Port Saint Lucie to Key Largo.ExpandLaunch map view
  • Distance: 175.3 mi
  • Duration: 9h 25m

What companies run services between Port Saint Lucie, FL, USA and Key Largo, FL, USA?

You can take a bus from Fort Pierce to Key Largo Bus Stop via Sheridan Tri-Rail Station, Hollywood Sheridan Trirail Station, and Miami Airport Station in around 5h 15m.

Operators