Rome2Rio

Port Saint Lucie to Key West, FL buses

Find Transport to Key West, FL

View schedule

Trip Overview

The bus between Port Saint Lucie and Key West, FL takes 16h 10m. There is at least one bus per day from Port Saint Lucie to Key West, FL. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

16h 10m
Duration
278 mi
Distance
$71
Average price
Once daily
Frequency

Port Saint Lucie to Key West, FL bus times

Buses run once daily between Port Saint Lucie and Key West, FL. The service departs Port Saint Lucie at 9:00 PM at night, which arrives into Key West, FL at 13:10:00. All services require a transfer at Sheridan Tri-Rail Station and take an average of 16h 10m. The schedules shown below are for the next available departures.

Departing Friday, November 6, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USAKey West Transit16h 10m • 3 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USAKey West Transit16h 10m • 3 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USAKey West Transit16h 10m • 3 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USAKey West Transit16h 10m • 3 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USAKey West Transit16h 10m • 3 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Jet Set ExpressFlixbus USAGreyhound USAKey West Transit16h 10m • 3 changes

Frequently asked questions

Want to know about travelling from Port Saint Lucie to Key West, FL? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Port Saint Lucie to Key West, FL.ExpandLaunch map view
  • Distance: 277.8 mi
  • Duration: 16h 10m

What companies run services between Port Saint Lucie, FL, USA and Key West, FL, USA?

You can take a bus from Fort Pierce to Whitehead & Eaton via Sheridan Tri-Rail Station, Hollywood Sheridan Trirail Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 9h 50m.

Operators