Rome2Rio

Portland to Frederick buses

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Trip Overview

The average bus between Portland and Frederick takes 15h 33m and the fastest bus takes 12h 21m. The bus runs, on average, 5 times per week from Portland to Frederick. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 33m
Duration
620 mi
Distance
$208
Average price
5 times a week
Frequency

Portland to Frederick bus times

Buses run 5 times a week between Portland and Frederick. The service departs Portland at 11:59 PM at night, which arrives into Frederick at 12:20:00. All services require a transfer at New York Midtown and take an average of 15h 33m. The schedules shown below are for the next available departures.

Departing Friday, November 13, 2026

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    Arrives next day

    Flixbus USAFlixbus USABayRunner Shuttle12h 21m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Flixbus USAFlixbus USABayRunner Shuttle12h 21m • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Flixbus USAFlixbus USABayRunner Shuttle20h 21m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Flixbus USAFlixbus USABayRunner Shuttle12h 21m • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Flixbus USAFlixbus USABayRunner Shuttle20h 21m • 2 changes

Frequently asked questions

Want to know about travelling from Portland to Frederick? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Portland to Frederick.ExpandLaunch map view
  • Distance: 620.5 mi
  • Duration: 15h 33m

What companies run services between Portland, ME, USA and Frederick, MD, USA?

You can take a bus from City of Portland to Frederick via New York Midtown and Baltimore in around 13h 26m.

Operators