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Portland to Gainesville buses

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Trip Overview

The average bus between Portland and Gainesville takes 46h 9m and the fastest bus takes 45h 29m. The bus runs, on average, 3 times per week from Portland to Gainesville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

46h 9m
Duration
1,373 mi
Distance
$275
Average price
3 times a week
Frequency

Portland to Gainesville bus times

Buses run 3 times a week between Portland and Gainesville. The earliest departure is at 12:30 PM in the afternoon, and the last departure from Portland is at 2:30 PM which arrives into Gainesville at 11:59 AM. All services require a transfer at Boston, MA - South Station and take an average of 46h 9m. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

  •  → 

    Arrives +2 days

    Amtrak ThruwayGreyhound USAFlixbus USAFlixbus USA47h 29m • 3 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives +2 days

    Concord Coach LinesFlixbus USAFlixbus USAFlixbus USA45h 29m • 3 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Concord Coach LinesFlixbus USAFlixbus USAFlixbus USA45h 29m • 3 changes

Frequently asked questions

Want to know about travelling from Portland to Gainesville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Portland to Gainesville.ExpandLaunch map view
  • Distance: 1,372.6 mi
  • Duration: 46h 9m

What companies run services between Portland, ME, USA and Gainesville, FL, USA?

You can take a bus from Portland, ME to Gainesville via Boston, MA - South Station, Boston, Newark Penn Station, and Jacksonville in around 29h 29m.

Operators