Portland to Holyoke Buses

Portland to Holyoke buses

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Trip Overview

The average bus between Portland and Holyoke takes 5h 47m and the fastest bus takes 4h 14m. The bus service runs several times per day from Portland to Holyoke. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 47m
Duration: 202 mi
Distance: $46
Average price: Every 3 hours
Frequency

Bus via Boston

best

Take the bus from Portland, ME to Boston, MA - South Stationbus Portland / ...
Take the bus from Boston to Springfield Union Stationbus Greyhound US0240 / ...

4h 52m

$35–80

Portland to Holyoke bus times

Buses run every 3 hours between Portland and Holyoke. The earliest departure is at 4:15 AM at night, and the last departure from Portland is at 8:00 PM which arrives into Holyoke at 6:44 AM. All services require a transfer at Boston, MA - South Station and take an average of 5h 47m. The schedules shown below are for the next available departures.

Departing Thursday, October 22, 2026

8:30 AM → 12:45 PM
4h 15m • 2 changes
10:30 AM → 2:45 PM
4h 15m • 2 changes
11:30 AM → 4:15 PM
4h 45m • 2 changes
12:30 PM → 6:14 PM
5h 44m • 2 changes
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Departing Friday, October 23, 2026

4:15 AM → 9:15 AM
5h • 2 changes
5:15 AM → 10:45 AM
5h 30m • 2 changes
8:30 AM → 12:45 PM
4h 15m • 2 changes
10:30 AM → 2:45 PM
4h 15m • 2 changes
Show more

Departing Saturday, October 24, 2026

4:15 AM → 9:15 AM
5h • 2 changes
5:15 AM → 10:45 AM
5h 30m • 2 changes
8:30 AM → 12:45 PM
4h 15m • 2 changes
10:30 AM → 2:45 PM
4h 15m • 2 changes
Show more

Departing Sunday, October 25, 2026

4:15 AM → 9:14 AM
4h 59m • 2 changes
5:15 AM → 10:44 AM
5h 29m • 2 changes
8:30 AM → 12:44 PM
4h 14m • 2 changes
10:30 AM → 2:44 PM
4h 14m • 2 changes
Show more

Departing Monday, October 26, 2026

4:15 AM → 9:15 AM
5h • 2 changes
5:15 AM → 10:45 AM
5h 30m • 2 changes
8:30 AM → 12:45 PM
4h 15m • 2 changes
10:30 AM → 2:45 PM
4h 15m • 2 changes
Show more

Departing Tuesday, October 27, 2026

4:15 AM → 9:15 AM
5h • 2 changes
5:15 AM → 10:45 AM
5h 30m • 2 changes
8:30 AM → 12:45 PM
4h 15m • 2 changes
10:30 AM → 2:45 PM
4h 15m • 2 changes
Show more

Departing Wednesday, October 28, 2026

4:15 AM → 9:15 AM
5h • 2 changes
5:15 AM → 10:45 AM
5h 30m • 2 changes
8:30 AM → 12:45 PM
4h 15m • 2 changes
10:30 AM → 2:45 PM
4h 15m • 2 changes
Show more

Frequently asked questions

Want to know about travelling from Portland to Holyoke? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.