The average bus between Portland and Hyannis Transportation Center takes 4h 45m and the fastest bus takes 4h. There is a bus service every few hours from Portland to Hyannis Transportation Center. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Portland and Hyannis Transportation Center. The earliest departure is at 3:15 AM at night, and the last departure from Portland is at 8:00 PM which arrives into Hyannis Transportation Center at 1:35 AM. All services require a transfer at Boston, MA - South Station and take an average of 4h 45m. The schedules shown below are for the next available departures.

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Want to know about travelling from Portland to Hyannis Transportation Center? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Portland to Hyannis Transportation Center. However, there are services departing from Portland station and arriving at Hyannis Transportation Center station via Boston, MA - South Station station. The journey, including transfers, takes approximately 4h 45m.
Portland to Hyannis Transportation Center bus services, operated by Concord Coach Lines, depart from Portland, ME station.
Portland to Hyannis Transportation Center bus services, operated by Concord Coach Lines, arrive at Hyannis Transportation Center station.
The distance between Portland and Hyannis Transportation Center is 222.5 km. The road distance is 288 km.
You can take a bus from Portland, ME to Hyannis Transportation Center via Boston, MA - South Station and Boston South Buses in around 4h 27m.