Rome2Rio

Portland to Indianapolis buses

Find Transport to Indianapolis

View schedule
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

Trip Overview

The average bus between Portland and Indianapolis takes 28h 21m and the fastest bus takes 23h 45m. There is at least one bus per day from Portland to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

28h 21m
Duration
1,110 mi
Distance
$222
Average price
Once daily
Frequency

Portland to Indianapolis bus times

Buses run once daily between Portland and Indianapolis. The earliest departure is at 3:15 AM at night, and the last departure from Portland is at 8:00 PM which arrives into Indianapolis at 3:00 AM. All services require a transfer at Boston, MA - South Station and take an average of 28h 21m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Concord Coach LinesGreyhound USAFlixbus USA31h • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Concord Coach LinesGreyhound USAFlixbus USA31h • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Concord Coach LinesFlixbus USAFlixbus USA25h 30m • 2 changes
  •  → 

    Arrives +2 days

    Concord Coach LinesGreyhound USAFlixbus USA31h • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Concord Coach LinesFlixbus USAFlixbus USA25h 30m • 2 changes
  •  → 

    Arrives +2 days

    Concord Coach LinesGreyhound USAFlixbus USA31h • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Concord Coach LinesFlixbus USAFlixbus USA25h 30m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Amtrak ThruwayGreyhound USAFlixbus USA23h 45m • 2 changes

Frequently asked questions

Want to know about travelling from Portland to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Portland to Indianapolis.ExpandLaunch map view
  • Distance: 1,110.1 mi
  • Duration: 28h 21m

What companies run services between Portland, ME, USA and Indianapolis, IN, USA?

You can take a bus from Portland, ME to Indianapolis via Boston, MA - South Station, Boston, and Newark Penn Station in around 24h 45m.

Operators