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Portland to Key Largo buses

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Trip Overview

The average bus between Portland and Key Largo takes 40h 35m and the fastest bus takes 39h 55m. The bus runs, on average, 3 times per week from Portland to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

40h 35m
Duration
1,740 mi
Distance
$344
Average price
3 times a week
Frequency

Portland to Key Largo bus times

Buses run 3 times a week between Portland and Key Largo. The earliest departure is at 12:30 PM in the afternoon, and the last departure from Portland is at 2:30 PM which arrives into Key Largo at 6:25 AM. All services require a transfer at Boston, MA - South Station and take an average of 40h 35m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

  •  → 

    Arrives +2 days

    Concord Coach LinesFlixbus USAFlixbus USAGreyhound USA39h 55m • 3 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives +2 days

    Amtrak ThruwayGreyhound USAFlixbus USAGreyhound USA41h 55m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Concord Coach LinesFlixbus USAFlixbus USAGreyhound USA39h 55m • 3 changes

Frequently asked questions

Want to know about travelling from Portland to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Portland to Key Largo.ExpandLaunch map view
  • Distance: 1,740 mi
  • Duration: 40h 35m

What companies run services between Portland, ME, USA and Key Largo, FL, USA?

You can take a bus from Portland, ME to Key Largo Bus Stop via Boston, MA - South Station, Boston, Newark Penn Station, and Miami Airport Station in around 37h.

Operators