The average bus between Portland and Melrose takes 3h 52m and the fastest bus takes 2h 52m. There is a bus service every few hours from Portland to Melrose. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Portland and Melrose. The earliest departure is at 3:15 AM at night, and the last departure from Portland is at 8:00 PM which arrives into Melrose at 5:02 AM. All services require a transfer at Boston and take an average of 3h 52m. The schedules shown below are for the next available departures.


2h 52m • 2 changes


3h 10m • 2 changes


3h 41m • 2 changes


3h 12m • 2 changes


3h 18m • 2 changes


3h 4m • 2 changes


3h 22m • 2 changes


3h 23m • 2 changes


3h 18m • 2 changes


3h 4m • 2 changes


3h 22m • 2 changes


3h 23m • 2 changes


3h 18m • 2 changes


3h 4m • 2 changes


3h 22m • 2 changes


3h 23m • 2 changes
Want to know about travelling from Portland to Melrose? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Portland to Melrose. However, there are services departing from Portland station and arriving at Melrose station via Boston. The journey, including transfers, takes approximately 3h 52m.
Portland to Melrose bus services, operated by Concord Coach Lines, depart from City of Portland station.
Portland to Melrose bus services, operated by Concord Coach Lines, arrive at Boston station.
The distance between Portland and Melrose is 148.6 km. The road distance is 188 km.
Flixbus USA operates a bus from City of Portland to Boston twice daily. Tickets cost $17–29 and the journey takes 2h 1m. Greyhound USA also services this route twice daily.