Rome2Rio

Portland to Missouri buses

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Trip Overview

The average bus between Portland and Missouri takes 40h 17m and the fastest bus takes 38h 15m. The bus runs, on average, 6 times per week from Portland to Missouri. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

40h 17m
Duration
1,601 mi
Distance
$347
Average price
6 times a week
Frequency

Portland to Missouri bus times

Buses run 6 times a week between Portland and Missouri. The earliest departure is at 12:30 PM in the afternoon, and the last departure from Portland is at 2:30 PM which arrives into Missouri at 3:45 AM. All services require a transfer at Boston, MA - South Station and take an average of 40h 17m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Amtrak ThruwayGreyhound USAGreyhound USAGreyhound USA40h 15m • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Amtrak ThruwayGreyhound USAGreyhound USAGreyhound USA40h 15m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Concord Coach LinesFlixbus USAGreyhound USAGreyhound USA38h 15m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Concord Coach LinesFlixbus USAGreyhound USAGreyhound USA38h 15m • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Concord Coach LinesFlixbus USAGreyhound USAGreyhound USA38h 15m • 3 changes

Frequently asked questions

Want to know about travelling from Portland to Missouri? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Portland to Missouri.ExpandLaunch map view
  • Distance: 1,601.1 mi
  • Duration: 40h 17m

What companies run services between Portland, ME, USA and Missouri, USA?

You can take a bus from Portland, ME to Kansas City Bus Station via Boston, MA - South Station, Boston, Newark Penn Station, and St Louis Bus Station in around 36h.

Operators