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Portland to Myrtle Beach buses

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Trip Overview

The average bus between Portland and Myrtle Beach takes 22h 35m and the fastest bus takes 21h 5m. The bus runs, on average, 4 times per week from Portland to Myrtle Beach. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

22h 35m
Duration
1,058 mi
Distance
$217
Average price
4 times a week
Frequency

Portland to Myrtle Beach bus times

Buses run 4 times a week between Portland and Myrtle Beach. The earliest departure is at 12:30 PM in the afternoon, and the last departure from Portland is at 2:30 PM which arrives into Myrtle Beach at 11:35 AM. All services require a transfer at Boston, MA - South Station and take an average of 22h 35m. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

  •  → 

    Arrives next day

    Amtrak ThruwayGreyhound USAFlixbus USAGreyhound USA23h 5m • 3 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives next day

    Concord Coach LinesFlixbus USAFlixbus USAGreyhound USA21h 5m • 3 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives next day

    Concord Coach LinesFlixbus USAFlixbus USAGreyhound USA21h 5m • 3 changes

Frequently asked questions

Want to know about travelling from Portland to Myrtle Beach? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Portland to Myrtle Beach.ExpandLaunch map view
  • Distance: 1,058.3 mi
  • Duration: 22h 35m

What companies run services between Portland, ME, USA and Myrtle Beach, SC, USA?

You can take a bus from Portland, ME to Myrtle Beach Bus Station via Boston, MA - South Station, Boston, Newark Penn Station, and Fayetteville Bus Station in around 23h 40m.

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