The average bus between Portland and Waltham takes 3h 1m and the fastest bus takes 2h 40m. The bus service runs several times per day from Portland to Waltham. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Portland and Waltham. The earliest departure is at 3:15 AM at night, and the last departure from Portland is at 4:45 PM which arrives into Waltham at 7:25 PM. All services require a transfer at Boston, MA - South Station and take an average of 3h 1m. The schedules shown below are for the next available departures.

3h 25m • 1 change

2h 50m • 1 change

3h 7m • 1 change

2h 51m • 1 change

3h 12m • 1 change

2h 47m • 1 change

3h 21m • 1 change

3h 4m • 1 change

3h 12m • 1 change

2h 47m • 1 change

3h 21m • 1 change

3h 4m • 1 change

3h 12m • 1 change

2h 47m • 1 change

3h 21m • 1 change

3h 4m • 1 change

3h 12m • 1 change

2h 47m • 1 change

3h 21m • 1 change

3h 4m • 1 change
Want to know about travelling from Portland to Waltham? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Portland to Waltham. However, there are services departing from Portland station and arriving at Waltham station via Boston, MA - South Station station. The journey, including transfers, takes approximately 3h 1m.
Portland to Waltham bus services, operated by Amtrak Thruway, depart from Portland, ME station.
Portland to Waltham bus services, operated by Amtrak Thruway, arrive at Moody St @ Carter St station.
The distance between Portland and Waltham is 163.1 km. The road distance is 193 km.
You can take a bus from Portland, ME to Moody St @ Carter St via Boston, MA - South Station and Federal St @ Franklin St in around 3h 43m.