The average bus between Portland and Santa Cruz takes 28h 2m and the fastest bus takes 20h 51m. There is at least one bus per day from Portland to Santa Cruz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Portland and Santa Cruz. The earliest departure is at 12:35 AM at night, and the last departure from Portland is at 6:50 PM which arrives into Santa Cruz at 3:41 PM. All services require a transfer at Sacramento Bus Station and take an average of 28h 2m. The schedules shown below are for the next available departures.
Arrives next day



30h 30m • 3 changes
Arrives next day



20h 51m • 3 changes
Arrives next day



32h 20m • 3 changes
Arrives next day



21h 36m • 3 changes
Want to know about travelling from Portland to Santa Cruz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Portland to Santa Cruz. However, there are services departing from Portland station and arriving at Santa Cruz station via Sacramento Bus Station station. The journey, including transfers, takes approximately 28h 2m.
Portland to Santa Cruz bus services, operated by Greyhound USA, depart from Portland Curbside Bus Stop station.
Portland to Santa Cruz bus services, operated by Greyhound USA, arrive at Soquel Ave & Front station.
The distance between Portland and Santa Cruz is 952.2 km. The road distance is 1,187 km.
You can take a bus from Portland Curbside Bus Stop to Soquel Ave & Front via Sacramento Bus Station, Oakland, San Jose Diridon Station, and Diridon Station in around 19h 12m.