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Poughkeepsie to Cambridge buses

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Trip Overview

The average bus between Poughkeepsie and Cambridge takes 8h 22m and the fastest bus takes 8h 8m. The bus runs, on average, 5 times per week from Poughkeepsie to Cambridge. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

8h 22m
Duration
250 mi
Distance
$49
Average price
5 times a week
Frequency

Poughkeepsie to Cambridge bus times

Buses run 5 times a week between Poughkeepsie and Cambridge. The earliest departure is at 7:37 AM in the morning, and the last departure from Poughkeepsie is at 7:37 AM which arrives into Cambridge at 3:45 PM. All services require a transfer at TransCenter and take an average of 8h 22m. The schedules shown below are for the next available departures.

Departing Monday, October 19, 2026

  •  → 

    Leprechaun LinesGreyhound USAFlixbus USA8h 8m • 2 changes

Departing Tuesday, October 20, 2026

  •  → 

    Leprechaun LinesGreyhound USAGreyhound USA9h 18m • 2 changes

Departing Wednesday, October 21, 2026

  •  → 

    Leprechaun LinesGreyhound USAFlixbus USA8h 8m • 2 changes

Departing Thursday, October 22, 2026

  •  → 

    Leprechaun LinesGreyhound USAFlixbus USA8h 8m • 2 changes

Departing Friday, October 23, 2026

  •  → 

    Leprechaun LinesGreyhound USAFlixbus USA8h 8m • 2 changes

Frequently asked questions

Want to know about travelling from Poughkeepsie to Cambridge? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Poughkeepsie to Cambridge.ExpandLaunch map view
  • Distance: 250 mi
  • Duration: 8h 22m

What companies run services between Poughkeepsie, NY, USA and Cambridge, MA, USA?

You can take a bus from Metro North Station to Boston via TransCenter, White Plains Bus Station, and Hartford Union Station in around 7h 52m.

Operators