The average bus between Prague 1 and Berlin takes 5h 21m and the fastest bus takes 5h 8m. The bus service runs several times per day from Prague 1 to Berlin. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Prague 1 and Berlin. The earliest departure is at 6:10 AM in the morning, and the last departure from Prague 1 is at 5:42 PM which arrives into Berlin at 11:05 PM. All services require a transfer at Florenc and take an average of 5h 21m. The schedules shown below are for the next available departures.


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Want to know about travelling from Prague 1 to Berlin? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Prague 1 to Berlin. However, there are services departing from Prague 1 station and arriving at Berlin station via Berlin Südkreuz. The journey, including transfers, takes approximately 5h 21m.
Prague 1 to Berlin bus services, operated by Pražská integrovaná doprava, depart from Prague Florenc Central Bus Station.
Prague 1 to Berlin bus services, operated by Pražská integrovaná doprava, arrive at Berlin Südkreuz station.
Book your Prague 1 to Berlin bus tickets online with Pražská integrovaná doprava, RegioJet and FlixBus.
The distance between Prague 1 and Berlin is 279.9 km. The road distance is 346 km.
RegioJet operates a bus from Prague Florenc Central Bus Station to Berlin Südkreuz hourly. Tickets cost €23–35 and the journey takes 4h 15m.