The average bus between Prague 1 and Slovakia takes 4h 48m and the fastest bus takes 4h 32m. The bus service runs several times per day from Prague 1 to Slovakia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Prague 1 and Slovakia. The earliest departure is at 9:11 AM in the morning, and the last departure from Prague 1 is at 10:30 PM which arrives into Slovakia at 3:15 AM. All services require a transfer at Florenc and take an average of 4h 48m. The schedules shown below are for the next available departures.

4h 34m • 1 change
5h 19m • 1 changeArrives next day

4h 45m • 1 change
4h 32m • 1 change
5h 18m • 1 changeArrives next day

4h 45m • 1 changeWant to know about travelling from Prague 1 to Slovakia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Prague 1 to Slovakia. However, there are services departing from Prague 1 station and arriving at Slovakia station via Bratislava Mlynske Nivy Bus Station station. The journey, including transfers, takes approximately 4h 48m.
Prague 1 to Slovakia bus services, operated by Pražská integrovaná doprava, depart from Prague Florenc Central Bus Station.
Prague 1 to Slovakia bus services, operated by Pražská integrovaná doprava, arrive at Bratislava Mlynske Nivy Bus Station.
The distance between Prague 1 and Slovakia is 394.1 km. The road distance is 343 km.
RegioJet operates a bus from Prague Florenc Central Bus Station to Bratislava Mlynske Nivy Bus Station 3 times a day. Tickets cost €22–35 and the journey takes 4h 15m. Slovak Lines also services this route once daily.