The average bus between Prague Castle and Brno takes 3h 9m and the fastest bus takes 2h 50m. There is a bus service every few hours from Prague Castle to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Prague Castle and Brno. The earliest departure is at 7:35 AM in the morning, and the last departure from Prague Castle is at 8:10 PM which arrives into Brno at 11:20 PM. All services require a transfer at Prague and take an average of 3h 9m. The schedules shown below are for the next available departures.

2h 55m • 1 change

4h • 1 change

3h 10m • 1 change

3h • 1 change

2h 55m • 1 change

3h 20m • 1 change

3h • 1 change

3h 15m • 1 change

2h 55m • 1 change

3h 20m • 1 change

3h • 1 change

3h 15m • 1 change

2h 55m • 1 change

3h 55m • 1 change

3h • 1 change

3h 15m • 1 change

2h 55m • 1 change

3h 20m • 1 change

3h • 1 change

3h 15m • 1 change
Want to know about travelling from Prague Castle to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Prague Castle to Brno. However, there are services departing from Prague Castle station and arriving at Brno station via Brno. The journey, including transfers, takes approximately 3h 9m.
Prague Castle to Brno bus services, operated by FlixBus, depart from Praha, ÚAN Florenc station.
Prague Castle to Brno bus services, operated by FlixBus, arrive at Brno station.
Book your Prague Castle to Brno bus tickets online with FlixBus and RegioJet.
The distance between Prague Castle and Brno is 188.3 km. The road distance is 223 km.
FlixBus operates a bus from Praha, ÚAN Florenc to Brno hourly. Tickets cost Kč 440–750 and the journey takes 2h 55m. RegioJet also services this route once daily.