The average bus between Prague (Station) and Berlin takes 5h 4m and the fastest bus takes 4h 50m. The bus service runs several times per day from Prague (Station) to Berlin. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Prague (Station) and Berlin. The earliest departure is at 6:30 AM in the morning, and the last departure from Prague (Station) is at 6:00 PM which arrives into Berlin at 11:05 PM. All services require a transfer at Berlin Südkreuz and take an average of 5h 4m. The schedules shown below are for the next available departures.

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5h 25m • 1 changeWant to know about travelling from Prague (Station) to Berlin? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Prague (Station) to Berlin. However, there are services departing from Prague (Station) station and arriving at Berlin station via Berlin Südkreuz. The journey, including transfers, takes approximately 5h 4m.
Prague (Station) to Berlin bus services, operated by RegioJet, depart from Prague Florenc Central Bus Station.
Prague (Station) to Berlin bus services, operated by RegioJet, arrive at Berlin Südkreuz station.
Book your Prague (Station) to Berlin bus tickets online with RegioJet and FlixBus.
The distance between Prague (Station) and Berlin is 280.1 km. The road distance is 342 km.
RegioJet operates a bus from Prague Florenc Central Bus Station to Berlin Südkreuz hourly. Tickets cost €22–35 and the journey takes 4h 15m.