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Prague hl.n. to Brno buses

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Trip Overview

The average bus between Prague hl.n. and Brno takes 2h 32m and the fastest bus takes 2h 25m. The bus service runs several times per day from Prague hl.n. to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2h 32m
Duration
206 km
Distance
Kč 500
Average price
Every 3 hours
Frequency

Prague hl.n. to Brno bus times

Buses run every 3 hours between Prague hl.n. and Brno. The earliest departure is at 1:45 AM at night, and the last departure from Prague hl.n. is at 11:25 PM which arrives into Brno at 1:55 AM. All services run direct with no transfers required, and take on average 2h 32m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

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    Arrives next day

    bus bus 2h 30m • Direct

Departing Sunday, November 8, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 25m • Direct
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    bus bus 2h 25m • Direct
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    bus bus 2h 30m • Direct
  • Show more

Departing Monday, November 9, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 25m • Direct
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    bus bus 2h 25m • Direct
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    bus bus 2h 30m • Direct
  • Show more

Departing Tuesday, November 10, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 30m • Direct
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    bus bus 2h 30m • Direct
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    bus bus 2h 35m • Direct
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Departing Wednesday, November 11, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 30m • Direct
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    bus bus 2h 30m • Direct
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    bus bus 2h 35m • Direct
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Departing Thursday, November 12, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 25m • Direct
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    bus bus 2h 25m • Direct
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    bus bus 2h 30m • Direct
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Departing Friday, November 13, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 25m • Direct
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    bus bus 2h 25m • Direct
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    bus bus 2h 30m • Direct
  • Show more

Frequently asked questions

Want to know about travelling from Prague hl.n. to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Prague hl.n. to Brno.ExpandLaunch map view
  • Distance: 205.8 km
  • Duration: 2h 32m

What companies run services between Prague hl.n., Czechia and Brno, Czechia?

FlixBus operates a bus from Praha, Hlavní Nádraží to Brno hourly. Tickets cost Kč 440–700 and the journey takes 2h 35m. České dráhy (ČD) also services this route twice a week.

Operators