The average bus between Prague and Berlin (State) takes 4h 51m and the fastest bus takes 4h 45m. The bus service runs several times per day from Prague to Berlin (State). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Prague and Berlin (State). The earliest departure is at 6:30 AM in the morning, and the last departure from Prague is at 6:00 PM which arrives into Berlin (State) at 10:53 PM. All services require a transfer at Berlin Südkreuz and take an average of 4h 51m. The schedules shown below are for the next available departures.

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Want to know about travelling from Prague to Berlin (State)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Prague to Berlin (State). However, there are services departing from Prague station and arriving at Berlin (State) station via Berlin Südkreuz. The journey, including transfers, takes approximately 4h 51m.
Prague to Berlin (State) bus services, operated by RegioJet, depart from Prague Florenc Central Bus Station.
Prague to Berlin (State) bus services, operated by RegioJet, arrive at Berlin Südkreuz station.
Book your Prague to Berlin (State) bus tickets online with RegioJet and BVG.
The distance between Prague and Berlin (State) is 277.1 km. The road distance is 343 km.
RegioJet operates a bus from Prague Florenc Central Bus Station to Berlin Südkreuz hourly. Tickets cost €24–35 and the journey takes 4h 15m.