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Prague to Brno Main Train Station buses

Find Transport to Brno Main Train Station

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Trip Overview

The average bus between Prague and Brno Main Train Station takes 2h 41m and the fastest bus takes 2h 30m. There is an hourly bus service from Prague to Brno Main Train Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2h 41m
Duration
217 km
Distance
Kč 500
Average price
Hourly
Frequency

Prague to Brno Main Train Station bus times

Buses run hourly between Prague and Brno Main Train Station. The earliest departure is at 3:35 AM at night, and the last departure from Prague is at 11:15 PM which arrives into Brno Main Train Station at 1:55 AM. All services run direct with no transfers required, and take on average 2h 41m. The schedules shown below are for the next available departures.

Departing Friday, October 16, 2026

  •  → 

    bus bus 2h 55m • Direct
  •  → 

    bus bus 2h 45m • Direct
  •  → 

    bus bus 2h 55m • Direct
  •  → 

    bus bus 2h 35m • Direct
  • Show more

Departing Saturday, October 17, 2026

  •  → 

    bus bus 2h 35m • Direct
  •  → 

    bus bus 2h 45m • Direct
  •  → 

    bus bus 2h 40m • Direct
  •  → 

    bus bus 2h 40m • Direct
  • Show more

Departing Sunday, October 18, 2026

  •  → 

    bus bus 2h 35m • Direct
  •  → 

    bus bus 2h 45m • Direct
  •  → 

    bus bus 2h 40m • Direct
  •  → 

    bus bus 2h 40m • Direct
  • Show more

Frequently asked questions

Want to know about travelling from Prague to Brno Main Train Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Prague to Brno Main Train Station.ExpandLaunch map view
  • Distance: 217 km
  • Duration: 2h 41m

What companies run services between Prague, Czechia and Brno Main Train Station, Czechia?

FlixBus operates a bus from Praha, ÚAN Florenc to Brno hourly. Tickets cost Kč 430–700 and the journey takes 2h 55m. RegioJet also services this route once daily.

Operators