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Prague to Mainz-Kastel buses

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Trip Overview

The bus between Prague and Mainz-Kastel takes 8h 57m. There is at least one bus per day from Prague to Mainz-Kastel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

8h 57m
Duration
546 km
Distance
€49
Average price
Once daily
Frequency

Prague to Mainz-Kastel bus times

Buses run once daily between Prague and Mainz-Kastel. The earliest departure is at 3:25 AM at night, and the last departure from Prague is at 3:25 AM which arrives into Mainz-Kastel at 12:22 PM. All services require a transfer at Frankfurt Central Train Station and take an average of 8h 57m. The schedules shown below are for the next available departures.

Departing Thursday, October 8, 2026

  •  → 

    FlixBusMainzer Mobilität8h 57m • 1 change

Departing Friday, October 9, 2026

  •  → 

    FlixBusMainzer Mobilität8h 57m • 1 change

Departing Saturday, October 10, 2026

  •  → 

    FlixBusMainzer Mobilität8h 57m • 1 change

Departing Sunday, October 11, 2026

  •  → 

    FlixBusMainzer Mobilität9h 3m • 1 change

Departing Monday, October 12, 2026

  •  → 

    FlixBusMainzer Mobilität8h 57m • 1 change

Departing Tuesday, October 13, 2026

  •  → 

    FlixBusMainzer Mobilität8h 57m • 1 change

Departing Wednesday, October 14, 2026

  •  → 

    FlixBusMainzer Mobilität8h 57m • 1 change

Frequently asked questions

Want to know about travelling from Prague to Mainz-Kastel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Prague to Mainz-Kastel.ExpandLaunch map view
  • Distance: 546 km
  • Duration: 8h 57m

What companies run services between Prague, Czechia and Mainz-Kastel, Hesse, Germany?

RegioJet operates a bus from Prague Florenc Central Bus Station to Frankfurt Central Train Station once daily. Tickets cost €30–50 and the journey takes 6h 25m.

Operators