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Prague to Nové Mesto buses

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Trip Overview

The average bus between Prague and Nové Mesto takes 6h 8m and the fastest bus takes 4h 40m. The bus service runs several times per day from Prague to Nové Mesto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 8m
Duration
345 km
Distance
€52
Average price
3 times a day
Frequency

Prague to Nové Mesto bus times

Buses run 3 times a day between Prague and Nové Mesto. The earliest departure is at 9:30 AM in the morning, and the last departure from Prague is at 11:00 PM which arrives into Nové Mesto at 5:10 AM. All services require a transfer at Bratislava Mlynske Nivy Bus Station and take an average of 6h 8m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

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    Arrives next day

    RegioJetSlovakia Public Transport6h 10m • 1 change

Departing Tuesday, November 10, 2026

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    RegioJetSlovakia Public Transport4h 42m • 1 change
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    RegioJetSlovakia Public Transport5h 24m • 1 change
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    Arrives next day

    RegioJetSlovakia Public Transport6h 10m • 1 change

Departing Wednesday, November 11, 2026

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    RegioJetSlovakia Public Transport4h 42m • 1 change
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    RegioJetSlovakia Public Transport5h 24m • 1 change
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    Arrives next day

    RegioJetSlovakia Public Transport6h 10m • 1 change

Departing Thursday, November 12, 2026

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    RegioJetSlovakia Public Transport4h 42m • 1 change
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    RegioJetSlovakia Public Transport5h 24m • 1 change
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    Arrives next day

    RegioJetSlovakia Public Transport6h 10m • 1 change

Departing Friday, November 13, 2026

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    RegioJetSlovakia Public Transport4h 42m • 1 change
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    RegioJetSlovakia Public Transport5h 24m • 1 change
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    Arrives next day

    RegioJetSlovakia Public Transport6h 9m • 1 change

Departing Saturday, November 14, 2026

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    RegioJetSlovakia Public Transport4h 40m • 1 change
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    Arrives next day

    RegioJetSlovakia Public Transport6h 9m • 1 change

Departing Sunday, November 15, 2026

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    RegioJetSlovakia Public Transport4h 40m • 1 change
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    RegioJetSlovakia Public Transport5h 24m • 1 change

Frequently asked questions

Want to know about travelling from Prague to Nové Mesto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Prague to Nové Mesto.ExpandLaunch map view
  • Distance: 345.5 km
  • Duration: 6h 8m

What companies run services between Prague, Czechia and Nové Mesto, Slovakia?

RegioJet operates a bus from Prague Florenc Central Bus Station to Bratislava Mlynske Nivy Bus Station 3 times a day. Tickets cost €22–35 and the journey takes 4h 15m. Slovak Lines also services this route once daily.

Operators