The average bus between Province of Rome (Region) and Siena takes 3h 50m and the fastest bus takes 3h 33m. The bus service runs several times per day from Province of Rome (Region) to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Province of Rome (Region) and Siena. The earliest departure is at 5:29 AM in the morning, and the last departure from Province of Rome (Region) is at 8:59 PM which arrives into Siena at 12:40 AM. All services require a transfer at Ponte Mammolo and take an average of 3h 50m. The schedules shown below are for the next available departures.


4h 5m • 2 changes


4h • 2 changes


3h 45m • 2 changes


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3h 45m • 2 changes


3h 48m • 2 changes


3h 55m • 2 changes


4h 10m • 2 changes


3h 45m • 2 changes


3h 48m • 2 changes


3h 55m • 2 changes


4h 10m • 2 changes


3h 33m • 2 changes


3h 50m • 2 changes


3h 55m • 2 changes


4h 5m • 2 changes


3h 33m • 2 changes


4h • 2 changes


3h 45m • 2 changes


3h 37m • 2 changes


4h • 2 changes


3h 45m • 2 changes


3h 37m • 2 changes


3h 54m • 2 changes
Want to know about travelling from Province of Rome (Region) to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Province of Rome (Region) to Siena. However, there are services departing from Province of Rome (Region) station and arriving at Siena station via Siena. The journey, including transfers, takes approximately 3h 50m.
Province of Rome (Region) to Siena bus services, operated by Cotral S.p.A., depart from Roma, Autostazione Tiburtina station.
Province of Rome (Region) to Siena bus services, operated by Cotral S.p.A., arrive at Siena station.
The distance between Province of Rome (Region) and Siena is 185.8 km. The road distance is 250 km.
FlixBus operates a bus from Roma, Autostazione Tiburtina to Siena every 3 hours. Tickets cost €20–35 and the journey takes 2h 39m. AutoLinee Moretti also services this route 3 times a week.