Bus Quality Hotel Nova Domus, Rome to Florence from €34 | Tickets & Timetables

Quality Hotel Nova Domus, Rome to Florence buses

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Trip Overview

The average bus between Quality Hotel Nova Domus, Rome and Florence takes 4h 22m and the fastest bus takes 3h 56m. There is a bus service every few hours from Quality Hotel Nova Domus, Rome to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 22m
Duration: 286 km
Distance: €34
Average price: Hourly
Frequency

Bus

best

Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus 510 / ...

4h 28m

€18–54

Quality Hotel Nova Domus, Rome to Florence bus times

Buses run hourly between Quality Hotel Nova Domus, Rome and Florence. The earliest departure is at 6:12 AM in the morning, and the last departure from Quality Hotel Nova Domus, Rome is at 10:09 PM which arrives into Florence at 2:10 AM. All services require a transfer at C.Ne Trionfale/Telesio and take an average of 4h 22m. The schedules shown below are for the next available departures.

Departing Friday, August 14, 2026

4:29 PM → 9:15 PM
4h 45m • 1 change
6:20 PM → 10:30 PM
4h 9m • 1 change
6:40 PM → 11:20 PM
4h 39m • 1 change
8:04 PM → 12:50 AM
Arrives next day
4h 45m • 1 change
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Departing Saturday, August 15, 2026

6:14 AM → 10:15 AM
4h 1m • 1 change
7:09 AM → 11:10 AM
4h • 1 change
8:03 AM → 12:15 PM
4h 11m • 1 change
8:27 AM → 12:45 PM
4h 17m • 1 change
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Departing Sunday, August 16, 2026

6:14 AM → 10:15 AM
4h 1m • 1 change
7:09 AM → 11:10 AM
4h • 1 change
8:03 AM → 12:15 PM
4h 11m • 1 change
8:27 AM → 12:45 PM
4h 17m • 1 change
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Departing Monday, August 17, 2026

6:12 AM → 10:15 AM
4h 2m • 1 change
7:09 AM → 11:10 AM
4h • 1 change
7:27 AM → 11:30 AM
4h 2m • 1 change
7:48 AM → 12:15 PM
4h 26m • 1 change
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Frequently asked questions

Want to know about travelling from Quality Hotel Nova Domus, Rome to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.