The average bus between Regensburg and Karlsruhe takes 6h 13m and the fastest bus takes 5h 46m. The bus service runs several times per day from Regensburg to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Regensburg and Karlsruhe. The earliest departure is at 1:35 AM at night, and the last departure from Regensburg is at 9:59 PM which arrives into Karlsruhe at 5:45 AM. All services require a transfer, and take on average 6h 13m. The schedules shown below are for the next available departures.

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Want to know about travelling from Regensburg to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Regensburg to Karlsruhe. However, there are services departing from Regensburg station and arriving at Karlsruhe station via Munich central bus station station. The journey, including transfers, takes approximately 6h 13m.
Regensburg to Karlsruhe bus services, operated by FlixBus, depart from Regensburg central train station.
Regensburg to Karlsruhe bus services, operated by FlixBus, arrive at Karlsruhe central train station.
Book your Regensburg to Karlsruhe bus tickets online with FlixBus and BlaBlaCar Bus.
The distance between Regensburg and Karlsruhe is 269.6 km. The road distance is 422 km.
You can take a bus from Regensburg central train station to Karlsruhe central train station via Munich central bus station in around 7h 11m.