The average bus between Regensburg and Karlsruhe takes 6h 33m and the fastest bus takes 5h 46m. The bus service runs several times per day from Regensburg to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Regensburg and Karlsruhe. The earliest departure is at 2:35 AM at night, and the last departure from Regensburg is at 10:59 PM which arrives into Karlsruhe at 5:45 AM. All services require a transfer, and take on average 6h 33m. The schedules shown below are for the next available departures.

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7h 20m • 1 changeWant to know about travelling from Regensburg to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Regensburg to Karlsruhe. However, there are services departing from Regensburg central train station and arriving at Karlsruhe central train station via Munich central bus station. The journey, including transfers, takes approximately 6h 33m.
Regensburg to Karlsruhe bus services, operated by FlixBus, depart from Regensburg central train station.
Regensburg to Karlsruhe bus services, operated by FlixBus, arrive at Karlsruhe central train station.
Book your Regensburg to Karlsruhe bus tickets online with Omio, FlixBus and 12go.asia.
The distance between Regensburg and Karlsruhe is 269.6 km. The road distance is 336 km.
You can take a bus from Regensburg central train station to Karlsruhe central train station via Munich central bus station in around 5h 32m.