Rome2Rio

Roanoke to Florence buses

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Trip Overview

The bus between Roanoke and Florence takes 29h 15m. The bus runs, on average, 3 times per week from Roanoke to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

29h 15m
Duration
491 mi
Distance
$102
Average price
3 times a week
Frequency

Roanoke to Florence bus times

Buses run 3 times a week between Roanoke and Florence. The service departs Roanoke at 4:25 AM at night, which arrives into Florence at 09:40:00. All services require a transfer at Lynchburg Transit Center and take an average of 29h 15m. The schedules shown below are for the next available departures.

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA29h 15m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA29h 15m • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA29h 15m • 3 changes

Frequently asked questions

Want to know about travelling from Roanoke to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Roanoke to Florence.ExpandLaunch map view
  • Distance: 491.3 mi
  • Duration: 29h 15m

What companies run services between Roanoke, VA, USA and Florence, SC, USA?

You can take a bus from Roanoke Bus Stop to Florence Bus Station via Lynchburg Transit Center, Richmond, Richmond, and Raleigh Bus Station in around 12h 35m.

Operators