Rome2Rio

Rochester to Indianapolis buses

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Trip Overview

The average bus between Rochester and Indianapolis takes 23h 24m and the fastest bus takes 23h 15m. The bus runs, on average, 6 times per week from Rochester to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

23h 24m
Duration
549 mi
Distance
$138
Average price
6 times a week
Frequency

Rochester to Indianapolis bus times

Buses run 6 times a week between Rochester and Indianapolis. The service departs Rochester at 12:35 PM in the afternoon, which arrives into Indianapolis at 12:45:00. All services require a transfer at Milwaukee and take an average of 23h 24m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA24h 10m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA23h 15m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA23h 15m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA23h 15m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA23h 15m • 2 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAFlixbus USA23h 15m • 2 changes

Frequently asked questions

Want to know about travelling from Rochester to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Rochester to Indianapolis.ExpandLaunch map view
  • Distance: 549.1 mi
  • Duration: 23h 24m

What companies run services between Rochester, MN, USA and Indianapolis, IN, USA?

You can take a bus from Rochester to Indianapolis via Milwaukee, Milwaukee Intermodal Station, and Chicago Bus Station in around 13h 5m.

Operators