Rome2Rio

Rochester to Florence buses

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Trip Overview

The bus between Rochester and Florence takes 21h 35m. The bus runs, on average, 4 times per week from Rochester to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

21h 35m
Duration
1,067 mi
Distance
$329
Average price
4 times a week
Frequency

Rochester to Florence bus times

Buses run 4 times a week between Rochester and Florence. The service departs Rochester at 12:05 PM in the afternoon, which arrives into Florence at 09:40:00. All services require a transfer at New York and take an average of 21h 35m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

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    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA21h 35m • 2 changes

Departing Tuesday, November 10, 2026

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    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA21h 35m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA21h 35m • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA21h 35m • 2 changes

Frequently asked questions

Want to know about travelling from Rochester to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Rochester to Florence.ExpandLaunch map view
  • Distance: 1,066.6 mi
  • Duration: 21h 35m

What companies run services between Rochester, NY, USA and Florence, SC, USA?

You can take a bus from Rochester to Florence, SC via New York, 42 St-Times Square, Canal St, and New York, NY in around 19h 38m.

Operators