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Rochester to Mechanicsburg buses

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Trip Overview

The average bus between Rochester and Mechanicsburg takes 41h 18m and the fastest bus takes 40h 38m. The bus runs, on average, 4 times per week from Rochester to Mechanicsburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

41h 18m
Duration
352 mi
Distance
$175
Average price
4 times a week
Frequency

Rochester to Mechanicsburg bus times

Buses run 4 times a week between Rochester and Mechanicsburg. The service departs Rochester at 1:20 PM in the afternoon, which arrives into Mechanicsburg at 05:58:03. All services require a transfer at Binghamton and take an average of 41h 18m. The schedules shown below are for the next available departures.

Departing Tuesday, October 27, 2026

  •  → 

    Arrives +2 days

    TrailwaysGreyhound USATrailwaysRabbit Transit40h 38m • 3 changes

Departing Wednesday, October 28, 2026

  •  → 

    Arrives +2 days

    TrailwaysGreyhound USATrailwaysRabbit Transit40h 38m • 3 changes

Departing Thursday, October 29, 2026

  •  → 

    Arrives +2 days

    TrailwaysGreyhound USATrailwaysRabbit Transit42h 21m • 3 changes

Departing Saturday, October 31, 2026

  •  → 

    Arrives +2 days

    TrailwaysGreyhound USATrailwaysRabbit Transit41h 38m • 3 changes

Frequently asked questions

Want to know about travelling from Rochester to Mechanicsburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Rochester to Mechanicsburg.ExpandLaunch map view
  • Distance: 352.5 mi
  • Duration: 41h 18m

What companies run services between Rochester, NY, USA and Mechanicsburg, Cumberland County, PA, USA?

You can take a bus from Rochester to E Main St & Arch St WB via Binghamton, Scranton, Pa, Harrisburg, Pa, and Market Square Transfer Center in around 10h 14m.

Operators