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Roma Ostiense to Siena buses

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Trip Overview

The average bus between Roma Ostiense and Siena takes 4h 42m and the fastest bus takes 3h 46m. There is at least one bus per day from Roma Ostiense to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 42m
Duration
242 km
Distance
€28
Average price
Once daily
Frequency

Roma Ostiense to Siena bus times

Buses run once daily between Roma Ostiense and Siena. The earliest departure is at 5:20 AM in the morning, and the last departure from Roma Ostiense is at 5:28 AM which arrives into Siena at 9:15 AM. All services require a transfer at Ostiense/Mercati Generali and take an average of 4h 42m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

  •  → 

    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 54m • 1 change

Departing Sunday, November 8, 2026

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    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 46m • 1 change

Departing Monday, November 9, 2026

  •  → 

    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 54m • 1 change

Departing Tuesday, November 10, 2026

  •  → 

    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 54m • 1 change

Departing Wednesday, November 11, 2026

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    ATAC S.p.A. Azienda per la mobilitàFlixBus9h 39m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 54m • 1 change

Departing Friday, November 13, 2026

  •  → 

    ATAC S.p.A. Azienda per la mobilitàFlixBus3h 54m • 1 change

Frequently asked questions

Want to know about travelling from Roma Ostiense to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Roma Ostiense to Siena.ExpandLaunch map view
  • Distance: 242 km
  • Duration: 4h 42m

What companies run services between Roma Ostiense, Italy and Siena, Italy?

FlixBus operates a bus from Roma, Autostazione Tiburtina to Siena hourly. Tickets cost €20–30 and the journey takes 2h 40m. AutoLinee Moretti also services this route 3 times a week.

Operators