The average bus between Rome Termini and Brindisi takes 7h 58m and the fastest bus takes 7h 51m. The bus service runs several times per day from Rome Termini to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Rome Termini and Brindisi. The earliest departure is at 8:32 AM in the morning, and the last departure from Rome Termini is at 11:13 PM which arrives into Brindisi at 7:15 AM. All services require a transfer at Indipendenza and take an average of 7h 58m. The schedules shown below are for the next available departures.

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Want to know about travelling from Rome Termini to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome Termini to Brindisi. However, there are services departing from Rome Termini station and arriving at Brindisi station via Brindisi. The journey, including transfers, takes approximately 7h 58m.
Rome Termini to Brindisi bus services, operated by ATAC S.p.A. Azienda per la mobilità, depart from Roma, Autostazione Tiburtina station.
Rome Termini to Brindisi bus services, operated by ATAC S.p.A. Azienda per la mobilità, arrive at Brindisi station.
Book your Rome Termini to Brindisi bus tickets online with ATAC S.p.A. Azienda per la mobilità and FlixBus.
The distance between Rome Termini and Brindisi is 475.6 km. The road distance is 543 km.
FlixBus operates a bus from Roma, Autostazione Tiburtina to Brindisi 5 times a day. Tickets cost €45–75 and the journey takes 7h 25m.