The average bus between Rome Termini and Siena Station takes 3h 17m and the fastest bus takes 3h 2m. The bus service runs several times per day from Rome Termini to Siena Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Rome Termini and Siena Station. The earliest departure is at 5:59 AM in the morning, and the last departure from Rome Termini is at 9:20 PM which arrives into Siena Station at 12:40 AM. All services require a transfer at Indipendenza and take an average of 3h 17m. The schedules shown below are for the next available departures.

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3h 2m • 1 change
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3h 26m • 1 change
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3h 11m • 1 change
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3h 22m • 1 change
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3h 16m • 1 change
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3h 26m • 1 changeWant to know about travelling from Rome Termini to Siena Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome Termini to Siena Station. However, there are services departing from Roma, Autostazione Tiburtina station and arriving at Siena station via Siena station. The journey, including transfers, takes approximately 3h 17m.
Rome Termini to Siena Station bus services, operated by FlixBus, depart from Roma, Autostazione Tiburtina station.
Rome Termini to Siena Station bus services, operated by FlixBus, arrive at Siena station.
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The distance between Rome Termini and Siena Station is 185.8 km. The road distance is 231 km.
FlixBus operates a bus from Roma, Autostazione Tiburtina to Siena hourly. Tickets cost €20–30 and the journey takes 2h 40m. AutoLinee Moretti also services this route 3 times a week.