Rome Vatican to Florence Buses

Rome Vatican to Florence buses

Travel from

Search accommodation with Expedia

Trip Overview

The average bus between Rome Vatican and Florence takes 4h 13m and the fastest bus takes 3h 45m. There is a bus service every few hours from Rome Vatican to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 13m
Duration: 286 km
Distance: €34
Average price: Hourly
Frequency

Bus

best

Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus 510 / ...

4h 34m

€16–48

Rome Vatican to Florence bus times

Buses run hourly between Rome Vatican and Florence. The earliest departure is at 5:44 AM in the morning, and the last departure from Rome Vatican is at 10:24 PM which arrives into Florence at 2:10 AM. All services require a transfer at Lepanto and take an average of 4h 13m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

7:15 AM → 11:10 AM
3h 54m • 1 change
7:30 AM → 11:45 AM
4h 14m • 1 change
8:02 AM → 12:30 PM
4h 27m • 1 change
8:45 AM → 12:45 PM
3h 59m • 1 change
Show more

Departing Tuesday, November 10, 2026

5:53 AM → 10:15 AM
4h 21m • 1 change
7:15 AM → 11:10 AM
3h 54m • 1 change
7:30 AM → 11:45 AM
4h 14m • 1 change
8:02 AM → 12:30 PM
4h 27m • 1 change
Show more

Departing Wednesday, November 11, 2026

7:15 AM → 11:10 AM
3h 54m • 1 change
7:30 AM → 11:45 AM
4h 14m • 1 change
8:02 AM → 12:30 PM
4h 27m • 1 change
9:25 AM → 1:25 PM
3h 59m • 1 change
Show more

Departing Thursday, November 12, 2026

5:53 AM → 10:15 AM
4h 21m • 1 change
7:15 AM → 11:10 AM
3h 54m • 1 change
7:30 AM → 11:45 AM
4h 14m • 1 change
8:02 AM → 12:30 PM
4h 27m • 1 change
Show more

Departing Friday, November 13, 2026

5:53 AM → 10:15 AM
4h 21m • 1 change
7:15 AM → 11:10 AM
3h 54m • 1 change
7:30 AM → 11:45 AM
4h 14m • 1 change
8:02 AM → 12:30 PM
4h 27m • 1 change
Show more

Departing Saturday, November 14, 2026

5:49 AM → 10:15 AM
4h 25m • 1 change
7:04 AM → 11:10 AM
4h 5m • 1 change
7:28 AM → 11:45 AM
4h 16m • 1 change
7:54 AM → 12:30 PM
4h 35m • 1 change
Show more

Departing Sunday, November 15, 2026

5:44 AM → 10:15 AM
4h 30m • 1 change
7:04 AM → 11:10 AM
4h 5m • 1 change
7:30 AM → 11:45 AM
4h 14m • 1 change
8:18 AM → 12:30 PM
4h 11m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Rome Vatican to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.