The average bus between Rome and Medicina takes 6h 31m and the fastest bus takes 5h 20m. The bus service runs several times per day from Rome to Medicina. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Rome and Medicina. The earliest departure is at 12:40 AM at night, and the last departure from Rome is at 7:25 AM which arrives into Medicina at 5:58 PM. All services require a transfer, and take on average 6h 31m. The schedules shown below are for the next available departures.

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8h 30m • 1 change

6h 8m • 1 change

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6h 8m • 1 change

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8h 30m • 1 change
Want to know about travelling from Rome to Medicina? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome to Medicina. However, there are services departing from Rome station and arriving at Medicina station via Bologna Autostazione. The journey, including transfers, takes approximately 6h 31m.
Rome to Medicina bus services, operated by Itabus S.p.A., depart from Rome Tiburtina Largo Mazzoni station.
Rome to Medicina bus services, operated by Itabus S.p.A., arrive at Bologna Autostazione station.
The distance between Rome and Medicina is 294.8 km. The road distance is 424 km.
Itabus S.p.A. operates a bus from Rome Tiburtina Largo Mazzoni to Bologna Autostazione every 4 hours. Tickets cost €24–50 and the journey takes 5h 15m. Two other operators also service this route.