The average bus between Rome and San Donnino takes 4h 9m and the fastest bus takes 3h 17m. The bus service runs several times per day from Rome to San Donnino. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Rome and San Donnino. The earliest departure is at 6:15 AM in the morning, and the last departure from Rome is at 11:20 PM which arrives into San Donnino at 6:32 AM. All services require a transfer at Florence Villa Constanza Bus Station and take an average of 4h 9m. The schedules shown below are for the next available departures.

3h 17m • 1 change

5h 44m • 1 change
Arrives next day

7h 12m • 1 change

3h 17m • 1 change

5h 44m • 1 change
Arrives next day

7h 12m • 1 change

3h 17m • 1 change

5h 44m • 1 change
Arrives next day

7h 12m • 1 change
Want to know about travelling from Rome to San Donnino? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome to San Donnino. However, there are services departing from Rome station and arriving at San Donnino station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 4h 9m.
Rome to San Donnino bus services, operated by FlixBus, depart from Rome Tiburtina Largo Mazzoni station.
Rome to San Donnino bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
The distance between Rome and San Donnino is 237.7 km. The road distance is 303 km.
Itabus S.p.A. operates a bus from Rome Tiburtina Largo Mazzoni to Florence Villa Constanza Bus Station every 4 hours. Tickets cost €18–40 and the journey takes 3h 50m. Two other operators also service this route.