The average bus between Rome and Sesto Fiorentino takes 4h 53m and the fastest bus takes 3h 53m. The bus service runs several times per day from Rome to Sesto Fiorentino. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Rome and Sesto Fiorentino. The earliest departure is at 1:30 AM at night, and the last departure from Rome is at 10:45 PM which arrives into Sesto Fiorentino at 6:53 AM. All services require a transfer at Florence and take an average of 4h 53m. The schedules shown below are for the next available departures.

5h 23m • 1 change
Arrives next day

4h 35m • 1 change
Arrives next day

3h 53m • 1 change
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8h 8m • 1 change
Arrives next day

4h 35m • 1 change
Arrives next day

3h 53m • 1 change
Arrives next day

8h 8m • 1 change
Arrives next day

4h 35m • 1 change
Arrives next day

3h 53m • 1 change

5h 23m • 1 change
Arrives next day

4h 35m • 1 change
Arrives next day

3h 53m • 1 change
Want to know about travelling from Rome to Sesto Fiorentino? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome to Sesto Fiorentino. However, there are services departing from Rome station and arriving at Sesto Fiorentino station via Florence. The journey, including transfers, takes approximately 4h 53m.
Rome to Sesto Fiorentino bus services, operated by FlixBus, depart from Roma, Autostazione Tiburtina station.
Rome to Sesto Fiorentino bus services, operated by FlixBus, arrive at Florence station.
Book your Rome to Sesto Fiorentino bus tickets online with FlixBus and Autolinee Toscane.
The distance between Rome and Sesto Fiorentino is 239.4 km. The road distance is 283 km.
FlixBus operates a bus from Roma, Autostazione Tiburtina to Florence 5 times a day. Tickets cost €24–40 and the journey takes 3h 25m.