Rome2Rio

Rome to Southern Europe buses

Find Transport to Southern Europe

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Trip Overview

The bus between Rome and Southern Europe takes 2d 22h. The bus runs, on average, once a week from Rome to Southern Europe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 22h
Duration
2,387 km
Distance
€219
Average price
Once a week
Frequency

Rome to Southern Europe bus times

Buses run once a week between Rome and Southern Europe. The service departs Rome at 9:45 PM at night, which arrives into Southern Europe at 19:53:00. All services require a transfer at Lyon - Gerland Bus Station and take an average of 2d 22h. The schedules shown below are for the next available departures.

Departing Tuesday, October 13, 2026

  •  → 

    Arrives +3 days

    Itabus S.p.A.FlixBusALSALinecar2d 22h • 3 changes

Frequently asked questions

Want to know about travelling from Rome to Southern Europe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Rome to Southern Europe.ExpandLaunch map view
  • Distance: 2,387 km
  • Duration: 2d 22h

What companies run services between Rome, Italy and Southern Europe, Spain?

You can take a bus from Roma, Autostazione Tiburtina to Estebanvela via Lyon - Gerland Bus Station, Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid), and Cerezo De Abajo in around 36h 28m.

Operators