The average bus between Rome and Staffoli takes 6h 4m and the fastest bus takes 3h 23m. The bus service runs several times per day from Rome to Staffoli. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Rome and Staffoli. The earliest departure is at 11:15 AM in the morning, and the last departure from Rome is at 9:00 PM which arrives into Staffoli at 7:25 AM. All services require a transfer, and take on average 6h 4m. The schedules shown below are for the next available departures.

3h 23m • 1 change

3h 53m • 1 change

4h 30m • 1 change
Arrives next day

12h 55m • 1 change

3h 23m • 1 change

3h 53m • 1 change

4h 30m • 1 change
Arrives next day

12h 55m • 1 change
Want to know about travelling from Rome to Staffoli? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome to Staffoli. However, there are services departing from Rome station and arriving at Staffoli station via Isernia. The journey, including transfers, takes approximately 6h 4m.
Rome to Staffoli bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., depart from Roma, Autostazione Tiburtina station.
Rome to Staffoli bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., arrive at Isernia station.
The distance between Rome and Staffoli is 151.2 km. The road distance is 200 km.
ATM Azienda di Trasporti Molisana S.p.A. operates a bus from Roma, Autostazione Tiburtina to Isernia 3 times a day. Tickets cost €8–13 and the journey takes 2h 10m. FlixBus also services this route once daily.