The average bus between Sète and Lyon takes 6h 1m and the fastest bus takes 5h 15m. The bus service runs several times per day from Sète to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Sète and Lyon. The earliest departure is at 7:05 AM in the morning, and the last departure from Sète is at 7:30 PM which arrives into Lyon at 1:10 AM. All services require a transfer at Montpellier - Sabines Tw2 and take an average of 6h 1m. The schedules shown below are for the next available departures.

5h • 1 change

4h 20m • 1 change

6h 15m • 1 change

3h 30m • 1 change

3h 15m • 1 change

5h • 1 change

4h 20m • 1 change

6h 15m • 1 change

3h 15m • 1 change

5h • 1 change

4h 20m • 1 change

6h 15m • 1 change

3h 15m • 1 change

5h • 1 change

4h 20m • 1 change

6h 15m • 1 change

3h 15m • 1 change

5h • 1 change

4h 20m • 1 change

6h 15m • 1 change
Want to know about travelling from Sète to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Sète to Lyon. However, there are services departing from Sète station and arriving at Lyon station via Montpellier - Sabines Tw2. The journey, including transfers, takes approximately 6h 1m.
Sète to Lyon bus services, operated by Hérault - liO Occitanie, depart from Sete - Noel Guignon station.
Sète to Lyon bus services, operated by Hérault - liO Occitanie, arrive at Lyon - Gerland Bus Station.
Book your Sète to Lyon bus tickets online with Hérault - liO Occitanie, FlixBus and BlaBlaCar Bus.
The distance between Sète and Lyon is 276.4 km. The road distance is 334 km.
You can take a bus from Sete - Noel Guignon to Lyon - Gerland Bus Station via Montpellier - Sabines Tw2 and Montpellier - Sabines Bus Station in around 4h 52m.